This boxy-looking crossover got some better variations from previous year versions. The V-6 models had optional projector-beam fog lamps with integrated step pad and revised headlamps. The seats were also upgraded and the interiors including the dash had wood finish and tinge of chrome work. The engines available were 143-hp 2.2-liter four-cylinder engine and 250-hp 3.5-liter V-6 engine. The former engine came with a five-speed manual gearbox or a four-speed automatic gearbox while the latter came with only a five-speed automatic gearbox. The 2006 Vue has the famous Red Line model with better interiors having leather seats, a six-way power driver seat adjustments and metallic foot pedals. Roof rails were newly added to all 2006 V-6 models except the Red Line model.
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